상악동내 국균증과 편평상피세포암의 동시발생 증례: 조직학적 연구 및 문헌고찰
Squamous cell carcinoma occurring with aspergillosis in the maxillary sinus: a case report and histological study
변준호, 이정희, 노규진, 박봉욱,
소속 상세정보
변준호 ( Byun June-Ho ) - 경상대학교 의학전문대학원 치과학교실 구강악안면외과
이정희 ( Lee Jeong-Hee ) - 경상대학교 의학전문대학원 치과학교실 구강악안면외과
노규진 ( Rho Gyu-Jin ) - 경상대학교 의학전문대학원 치과학교실 구강악안면외과
박봉욱 ( Park Bong-Wook ) - 경상대학교 의학전문대학원 치과학교실 구강악안면외과
KMID : 0355620100360020125
Abstract
The coexistence of aspergillosis and squamous cell carcinoma (SCC) in the maxillary sinus was very rare. To our knowledge, this is the second report of coexistent SCC and aspergillosis in the maxillary sinus. A 58-year-old man underwent surgery for unilateral maxillary sinus infection with oroantral fistula. In the surgical specimen, SCC and aspergillosis were co-detected with routine and immunohistochemical stainings. Moreover, human papillomavirus 18 (HPV-18) was detected by polymerase chain reaction in the sinus specimen. The patient was re-operated with subtotal maxillectomy and has been followed up for two years without any evidence of recurrence or metastasis. Although it is not understood how aspergillosis could induce carcinoma formation, the chronic inflammation caused by prolonged fungal infection might be carcinogenic. Moreover, HPV-16 and - 18 were another causative pathogens of SCC in the head and neck region. We recommend careful examination, including preoperative cytology, in patients with maxillary sinus fungal infections because of the potential for cancer development.
키워드
Aspergillosis;Squamous cell carcinoma;Maxillary sinus
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